Background: Pressure ulcers remain a prevalent concern in hospitals and the community. It affects any patient, regardless of age or gender yet, it is more prevalent in immobile patients. Aim of this research was: To assess influence of an instructional program on nurses’ performance related decreasing pressure ulcer and safety of immobilized patients. hypotheses: H1: The mean post-test nurses' knowledge and practice score will be considerably higher than pre-test knowledge and practice score. H2: Shows reduced pressure ulcer for patients after adopting program compared to preprogram participants. Design: A quasi-experimental design was adopted. Setting: This research was done in the orthopedic department of Benha University Hospital. sample: (convenience sample) all available nurses (n=50) &(Purposive sampling) (n=80) patients at orthopedic department Tools: four tools were utilized, I Interview Questionnaire, II Observational check list for nurses' practice ,III Braden Scale &Inpatient's' Assessment questionnaire Results: This study showed only 22 percent , 20of studied nurses had good level of total (knowledge, practice) about pressure ulcer at pre implementation of program, however immediately post implementation of program changed to 80 percent ,86 but after one month follow up slightly decline in level of knowledge was observed to 74 percent ,80 respectively. Conclusion The educational program is extremely efficient in improving (knowledge and practice) related lowering of pressure ulcer and Safety of immobilized orthopedic, which validated the research hypotheses Recommended Provide continual education and training sessions for nurses caring for immobilized patient to increase their knowledge and practice concerning pressure ulcer prevention.