Staff Members - Benha University
Ethnicity influences Breast Cancer Stem Cells Drug Resistance
• 2017
Publication Information
Authors
Mohamed Kamal, Ebtesam Nafie, Shimaa Elsers, Alanwar Salma, Ibrahim Rawayeh, Fatma Farag, Mohamed Mlees, Bruno Simoes, Kath Spence, Angélica, Santiago-Gómez, Mohamed Salem, Robert Clarke
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publication.type
International
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Supplementary Materials
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Abstract
Up to 70% of Breast Cancer (BC) patients relapse within 5 years. Al-Hajj et al. reported that a
subpopulation of cancer cells, Breast Cancer Stem Cells (BCSCs), has an inherent ability to resist drugs
and cause relapse [1]. The biology of BC have been shown to be different in patients from different
ethnic populations [2]. This racial variation is specifically evident in BCSCs resistance to chemotherapy.
In Vietnam, it was shown that CD44 is the main player in resistance of BCSCs to chemotherapy [3],
whereas in Japan, ALDH1 was proven to have a strong association with resistance to drugs [4]. In this
study, we tested the hypothesis that BCSCs are quantitatively different between European and African
ethnic groups and they use different mechanisms to resist therapy.
subpopulation of cancer cells, Breast Cancer Stem Cells (BCSCs), has an inherent ability to resist drugs
and cause relapse [1]. The biology of BC have been shown to be different in patients from different
ethnic populations [2]. This racial variation is specifically evident in BCSCs resistance to chemotherapy.
In Vietnam, it was shown that CD44 is the main player in resistance of BCSCs to chemotherapy [3],
whereas in Japan, ALDH1 was proven to have a strong association with resistance to drugs [4]. In this
study, we tested the hypothesis that BCSCs are quantitatively different between European and African
ethnic groups and they use different mechanisms to resist therapy.