In this study,the effects of fish diet contaminated with Cu, Cd and Cu +Cd on Nile tilapia, was
demonstrated by evaluating its bioaccumulation in the muscle and by testing the cytogenetic
profile. Fish exposed to diet contaminated with Cu, Cd or their mixture had a significant
increase in the number of chromosomal abnormalities and an inhibition of the mitotic
index. Our study revealed high muscle Cu or Cd content in fish fed with diet contaminated
with high dietborne Cu, Cd, Cu and Cd. It also revealed that the chromosomal abnormalities
were higher for fish fed diet Cd contaminated and Cu +Cd contaminated diets than those
fed diet Cu contaminated diet. Thus, maybe fish diets contaminated with Cu, Cd, Cu +Cd
induced genotoxicity and mutation. Also, maybe high concentrations of Cu and Cd in fish
tissue resulted from feeding on Cu and Cd contaminated diets, are dangerous for human
consumption.