Ventricular peritoneal shunts are considered to be permanent catheters with longterm complications. Management of ventricular peritoneal shunts presents major challenges later in children and their parents’ life, requiring multidisciplinary care from nurses. Aim This study was undertaken to evaluate the effects of nursing management protocols on mothers with children having ventricular peritoneal shunts. Research design A quasi-experimental design was used for the present study. Setting The present study was conducted at the Neurology Outpatient Clinic at Benha University Hospital followed by home visits. Sample A purposive sample of children visiting the Neurology Outpatient Clinic with ventricular peritoneal shunts during a period of 6 months was included. The study included 39 children. Two tools were used for data collection. A structured interview questionnaire was designed and consisted of four parts: part one included sociodemographic characteristics of the mother and child; part two included past and present medical history of the child; part three included mothers’ knowledge regarding ventricular peritoneal shunts, including its meaning, signs of infection, complications, prevention, and treatment; part four included others practices of mothers regarding ventricular peritoneal shunt care such as preventing of infection in the shunt area, preventing other infections, nutrition, treatment, and regular follow-up.