Vitiligo is a chronic skin disorder that may have a negative impact on patients’ self-esteem, quality of life and ultimately results in psychological problems. Aim of the study: This study aimed to assess correlation between psychological problems, self- esteem and quality of life among vitiligo patients. Research question: What is the correlation between psychological problems, self-esteem and quality of life among vitiligo patients? Design: A descriptive correlational research design was utilized in this study. Setting: The study was conducted at Benha dermatology hospital and dermatological outpatients at Benha University Hospital, Kaluobia Governorate. Sample: A random sample of 100 vitiligo patients was recruited consecutively from the above mentioned settings. Tools: Tool (1): A structured Interviewing Questionnaire Sheet, Tool (11): Depression Anxiety Stress Scale (DASS), Tool (111): Rosenberg' Self-Esteem Scale and Tool (V): Quality of Life Scale. Results: More than two thirds of the studied vitiligo patients had severe level of depression anxiety stress and more than half of them had low level of self-esteem and quality of life. Conclusion: There is a highly statistically significant negative correlation between mean scores of total depression anxiety stress, self-esteem and quality of life scales among the studied vitiligo patients. Recommendation: Stress management and assertiveness training program should be given to vitiligo patients to relieve their psychological problems and enhance their coping patterns.