BACKGROUND: The outbreak of coronavirus pandemic in Wuhan, China, since December 2019 has been the major public health concern. With the absence of an effective vaccine or treatment for the disease, current control measures are directed toward preventive measures to lessen disease burden and to curb the spread of the virus. AIM: The aim of the study was to assess knowledge, attitudes, perceptions, and practices (KAPP) of adult Egyptians toward COVID-19 and to study their determinants. METHODS: A community-based cross-sectional survey of a random sample of 999 Egyptian residence aged 16 years and above, it was conducted between April and June 2020 using self-administrated online questionnaire. It consisted of 15, five, and eight questions pertaining to knowledge, attitude, and practices toward COVID-19, respectively, in addition to demographic data. Data were analyzed using SPSS Statistics 23.0 at a level of significant at p ≤ 0.05. RESULTS: Out of the 999 participants, 628 (62.8%) were aged (20-