Staff Members - Benha University
Effect Of Exenatide, Metformin And Folic Acid On Experimentally Induced Metabolic–Cognitive Syndrome In Rats
benha medical journal • 2020
Publication Information
Authors
Ahmed F. Bahriz, Mohamed E. Mansour, Amany N. Ibrahim, Doaa M. Khalil and Heba A. El-Noury
Keywords
cognition, exenatide, folic acid, metabolic syndrome, metformin.
Journal
benha medical journal
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background: Metabolic syndrome (MetS) and its relationship with cognitive impairment has been the subject of extensive research.
Purpose: This study was designed to determine the effect of MetS on cognitive function, and the possibility of modulating this effect by exenatide, metformin and folic acid.
Materials and Methods: 30 adult male albino rats were divided in 5 groups. Group (I): received a standard rat chow, Group (II): MetS none treated rats fed with 60% fructose added to the standard rat chow, Group (III): MetS treated with exenatide, Group (IV): MetS treated with metformin, Group (V): MetS treated with folic acid. At the end of the experiment, fasting blood glucose, fasting plasma insulin, HOMA-IR index, serum triglyceride, HDL-C, dopamine and BDNF levels in brain tissue were measured and cognitive performance was assessed by Morris water maze (MWM) test.
Results: MetS rats increased fasting blood glucose, fasting plasma insulin, HOMA-IR index, arterial blood pressure, serum triglycerides and decreased HDL-C, dopamine and BDNF and showed memory impairment in MWM test. All treated groups resulted in decrease in fasting blood glucose, fasting plasma insulin, HOMA-IR index, arterial blood pressure, and serum triglycerides and increase in HDL-C, dopamine and BDNF. Also showed memory improvement in MWM test.
Conclusion: MetS was associated with cognitive impairment. Exenatide, metformin and folic acid improved cognitive function in addition to improvement of metabolic parameters.
Purpose: This study was designed to determine the effect of MetS on cognitive function, and the possibility of modulating this effect by exenatide, metformin and folic acid.
Materials and Methods: 30 adult male albino rats were divided in 5 groups. Group (I): received a standard rat chow, Group (II): MetS none treated rats fed with 60% fructose added to the standard rat chow, Group (III): MetS treated with exenatide, Group (IV): MetS treated with metformin, Group (V): MetS treated with folic acid. At the end of the experiment, fasting blood glucose, fasting plasma insulin, HOMA-IR index, serum triglyceride, HDL-C, dopamine and BDNF levels in brain tissue were measured and cognitive performance was assessed by Morris water maze (MWM) test.
Results: MetS rats increased fasting blood glucose, fasting plasma insulin, HOMA-IR index, arterial blood pressure, serum triglycerides and decreased HDL-C, dopamine and BDNF and showed memory impairment in MWM test. All treated groups resulted in decrease in fasting blood glucose, fasting plasma insulin, HOMA-IR index, arterial blood pressure, and serum triglycerides and increase in HDL-C, dopamine and BDNF. Also showed memory improvement in MWM test.
Conclusion: MetS was associated with cognitive impairment. Exenatide, metformin and folic acid improved cognitive function in addition to improvement of metabolic parameters.