| publication name | Role of KLF2: New insight in Inflammatory Acne Pathogenesis. KLF2 Predictor of Severity and Outcome in Acne |
|---|---|
| Authors | Menha A. Ibrahim MD¹, Shuzan Ali Mohammed MD ²and Doaa M. Elhabak, MD¹ |
| year | 2020 |
| keywords | Acne Vulgaris, Inflammatory Cytokines and KLF2. Accepted A |
| journal | |
| volume | Not Available |
| issue | Not Available |
| pages | Not Available |
| publisher | Not Available |
| Local/International | Local |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Summary Background: Acne is an inflammatory skin condition of pilosebaceous unit. Its pathogenesis is multifactorial with a central role of inflammatory and pro inflammatory cytokines mediators. Downregulated Kruppel like factor 2 (KLF2) leads to rapid secretion of many cytokines that are involved in acne pathogenesis. Aims: This study aimed at evaluating the level of KLF2 mRNA, clarifying its role in acne pathogenesis and its relation to acne lesion type, degree of severity and outcome. Patients and Methods: The level of KLF2 mRNA was measured in 100 patients with acne and 50 age and sex matched healthy controls by using quantitative real-time polymerase chain reaction (qRT-PCR). Results: The value of KLF2 mRNA was lower in acne patients than control group (P