Staff Members - Benha University
Role of KLF2: New insight in Inflammatory Acne Pathogenesis. KLF2 Predictor of Severity and Outcome in Acne
• 2020
Publication Information
Authors
Menha A. Ibrahim MD¹, Shuzan Ali Mohammed MD ²and Doaa M. Elhabak, MD¹
Keywords
Acne Vulgaris, Inflammatory Cytokines and KLF2.
Accepted A
Journal
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Publisher
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Volume
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Issue
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Pages
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publication.type
Local
Paper Link
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Supplementary Materials
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Abstract
Summary
Background: Acne is an inflammatory skin condition of pilosebaceous unit. Its
pathogenesis is multifactorial with a central role of inflammatory and pro inflammatory
cytokines mediators. Downregulated Kruppel like factor 2 (KLF2) leads to rapid secretion of
many cytokines that are involved in acne pathogenesis.
Aims: This study aimed at evaluating the level of KLF2 mRNA, clarifying its role in acne
pathogenesis and its relation to acne lesion type, degree of severity and outcome.
Patients and Methods: The level of KLF2 mRNA was measured in 100 patients with
acne and 50 age and sex matched healthy controls by using quantitative real-time polymerase
chain reaction (qRT-PCR).
Results: The value of KLF2 mRNA was lower in acne patients than control group (P
Background: Acne is an inflammatory skin condition of pilosebaceous unit. Its
pathogenesis is multifactorial with a central role of inflammatory and pro inflammatory
cytokines mediators. Downregulated Kruppel like factor 2 (KLF2) leads to rapid secretion of
many cytokines that are involved in acne pathogenesis.
Aims: This study aimed at evaluating the level of KLF2 mRNA, clarifying its role in acne
pathogenesis and its relation to acne lesion type, degree of severity and outcome.
Patients and Methods: The level of KLF2 mRNA was measured in 100 patients with
acne and 50 age and sex matched healthy controls by using quantitative real-time polymerase
chain reaction (qRT-PCR).
Results: The value of KLF2 mRNA was lower in acne patients than control group (P