Background: Myocardial infarction is a serious medical emergency, which leads to irreversible myocardial tissue death. Counseling based on health promotion model achieve higher level of well-being and behavior changes. Aim: To evaluate the effect of counseling program based on pender's health promotion model for patients with myocardial infarction. Design: the study design was a quasi-experimental Setting: The current study was conducted at cardiac outpatient clinic, affiliated to Benha University Hospital, Qalyubia Governorate. Sample: A purposive sample of 188 myocardial infarction patients was recruited. Tools: Three tools were used. I. A structured interviewing questionnaire , II. Health promoting lifestyle profile II. And III. Pender’s determinants of healthy behaviors. Results: Regarding patients' knowledge; pre program only 1.1% of the studied patients had good total knowledge regarding myocardial infarction, which increased to 71.3% post program. Pre program 9% of the studied patients were highly adhered to health promotion lifestyle, which increased to 55.3% post program. 28.2% of patients had good total behavior according to Pender's health promotion model pre program, which increased to 90.4% post program. Conclusion: The counseling program had a significant effect on the improvement of myocardial infarction patients' knowledge, health promotion lifestyle and pender's healthy behavior . Recommendations: - Further researches are required on a large scale on health promotion behavior for patients with myocardial infarction.