Background: The anesthesia may require high doses of hypnotics to manage signs of inadequate anesthesia or analgesia and its excessive use. The Bispectral Index (BIS) monitoring may be helpful in the titration of anesthetic agents more accurate than what is possible by standard clinical parameters. This study aimed to evaluate the value of the BIS index in anesthesia monitoring. Methods: one hundred patients scheduled for various elective surgical procedures were randomly allocated into two equal groups (n=50); Propofol total intravenous anesthesia (TIVA) and Isoflurane inhalational anesthesia. Each group is furtherly subdivided into two equal subgroups (n=25) according to whether BIS monitoring guided titration of anesthetics was used or only standard clinical practice. The results were assessed regarding; the consumption of anesthetics, recovery times and postoperative complications and the results were analyzed statistically. Results: BIS monitoring resulted in a lower Propofol infusion rate and lower end-tidal Isoflurane concentration in the BIS subgroups. Also, BIS monitoring resulted in shorter recovery times and less incidence of postoperative nausea and vomiting (PONV) in the BIS subgroups. Conclusion: Using the BIS index in patients undergoing surgical procedures under general anesthesia significantly decreases anesthesia consumption, improves recovery profile, and decreases postoperative PONV