Background: Infection with Helicobacter pylori (HP) is the most prevalent infection worldwide, particularly in underdeveloped nations. It is reported to be associated with many extra gastrointestinal manifestations. Objective: The current work aimed to study the prevalence of HP infection among patients with acute myocardial infarction (AMI). Patients and Methods: This cross-sectional study included STEMI and NSTEMI patients admitted with AMI in the CCU of the Cardiology Department at Benha University Hospital, Egypt. Results: The prevalence of HP among the studied patients was 72%. Our study showed that those with positive HP Ig-G had considerably lower triglycerides than those with negative HP Ig-G. No significant differences were observed regarding hemoglobin, TLC, platelets, serum creatinine, blood urea, ALT, AST, total cholesterol, HDL, and LDL. In patients with positive HP Ig-G, significant negative correlations were observed between ejection fraction (EF) and blood urea, serum creatinine, and AST. Conclusion: In this study, HP is related to the incidence of MI. The elimination of HP prevents the onset of CAD and associated consequences.