Aim of the work: A study to compare 6-month clinical outcome of immediate multivessel PCI versus staged PCI in patients with NSTE-ACS and multi-vessel disease. Patients and methods: Randomized study included 100 patients with NSTE-ACS who were admitted to the CCU at Benha university hospital divided into 2 groups; group I & group II. Results: The in-hospital outcome in group I was 10% and in group II was 14% , 2% of the cases with in-hospital cardiogenic shock in group I and 2% of the cases in group II, 4% of the cases with in-hospital heart failure in group I and 6% of the cases in group II, In-hospital CIN occurred in 4% of the cases in group I and in 8% of the cases in group II, and this differences did not show any statistical significance (P>0.05). The 6-months outcome was assessed in 7% of all cases divided into 8% in group I and 6% in group II while 6-months recurrence of angina was detected in 3% of all cases divided into 4% in group I and 2% of the case in group II. 6-months heart failure was found in 4% of the whole cases divided into 2 cases in each group but 6-months all-cause mortality. 6-months urgent TVR and 6-months non-fatal MI were not found in any cases in this study. All of those outcomes did not show any statistical significance (P>0.05). Conclusion: Immediate complete revascularization resulted in similar rates of in-hospital and 6-month outcomes compared to staged revascularization.