| publication name | (α -Aminoacyl)amino-substituted heterocycles and related compounds |
|---|---|
| Authors | Alan R. Katritzky , Bahaa El-Dien M. El-Gendy , Ekaterina Todadze and Ashraf A. A. Abdel-Fattah |
| year | 2008 |
| keywords | |
| journal | |
| volume | Not Available |
| issue | Not Available |
| pages | Not Available |
| publisher | Not Available |
| Local/International | International |
| Paper Link | http://pubs.acs.org/doi/abs/10.1021/jo8007379 |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
N-Protected-(aminoacyl)benzotriazoles 1a−e,g,i,j,1a′−c′ convert heterocyclic amines of the following series: thiazoles (3a and 3a′), benzothiazoles (3b and 3b′), benzimidazoles (3c and 3c′), thiadiazoles (3d), pyrimidones (9a,b,a′), pyrazoles (11a,b), and pyridines (13a−g, 13d′) under microwave irradiation, into N-substituted amides in yields of 40−98% (average 76%). N-Protected peptidoylbenzotriazoles 6a,b similarly afforded C-terminal N-protected dipeptidoyl amides 7a,b (52−60%).