Staff Members - Benha University
Comparison of the percentages of CD4+ CD25high FOXP3+ , CD4+ CD25low FOXP3+ , and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia
• 2017
Publication Information
Authors
Farha El-Chennawi1 | Ibrahim Mohamed Rageh2 | Amira Ibrahim Mansour2 |
Mohammed Ibrahim Darwish1 | Ashraf Antar Elghzaly1 | Basma El Sayed Sakr3 |
Khaled Mohsen Elbaz4
Keywords
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Pages
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publication.type
International
Paper Link
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Supplementary Materials
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Abstract
Problem: Little is known about how preeclampsia affects regulatory T-cell count and
functions in umbilical cord blood of babies born to preeclamptic mothers. Here, we
analyze the percentage of CD4+ CD25high FOXP3+
, CD4+ CD25low FOXP3+
, and
CD4+ FOXP3+
Tregs, in the umbilical cord blood of babies born to mothers with and
without preeclampsia.
Method of study: The percentage of umbilical cord blood CD4+ CD25high FOXP3+
,
CD4+ CD25low FOXP3+
, and CD4+ FOXP3+
Tregs were analyzed by flow cytometry.
Results: CD4+ CD25high FOXP3+
Treg (%) and CD4+ FOXP3+
Treg (%) were significantly lower, while CD4+ CD25low (%) was significantly higher in umbilical cord blood
of babies born to preeclamptic mothers.
Conclusion: Preeclampsia is associated with immune dysregulation which leads to a
deficiency in Treg (CD4+ CD25high FOXP3+
) in the umbilical cord blood of babies born
to preeclamptic mothers.
functions in umbilical cord blood of babies born to preeclamptic mothers. Here, we
analyze the percentage of CD4+ CD25high FOXP3+
, CD4+ CD25low FOXP3+
, and
CD4+ FOXP3+
Tregs, in the umbilical cord blood of babies born to mothers with and
without preeclampsia.
Method of study: The percentage of umbilical cord blood CD4+ CD25high FOXP3+
,
CD4+ CD25low FOXP3+
, and CD4+ FOXP3+
Tregs were analyzed by flow cytometry.
Results: CD4+ CD25high FOXP3+
Treg (%) and CD4+ FOXP3+
Treg (%) were significantly lower, while CD4+ CD25low (%) was significantly higher in umbilical cord blood
of babies born to preeclamptic mothers.
Conclusion: Preeclampsia is associated with immune dysregulation which leads to a
deficiency in Treg (CD4+ CD25high FOXP3+
) in the umbilical cord blood of babies born
to preeclamptic mothers.