Postoperative discharges teaching and follow-up are important services which can prevent unnecessary delays in discharge and assure the accessibility of adequate support afterward. Aim of the study was to evaluate the effectiveness of discharge educational program on quality of life and post- operative complications for children after cardiac surgery. Setting: The study was conducted at the cardiac surgery ward at Bahteem hospital affiliated to Ministry of Health in Bahteem city. Design: A quasi- experimental design was used to achieve the goal of this study. Subjects: 80 children accompanying their mothers were selected purposively and divided equally into study and control groups. Tools of data collection: Five tools were utilized; personal and medical data assessment sheets, knowledge assessment questionnaire, pediatric cardiac specific quality of life formats, pediatric quality of life scale and post-operative complications assessment sheet. Results: There was a highly statistical significant difference between study and control groups regarding total level of mother's knowledge (p˂0.001).The total quality of life and total cardiac specific quality of life for children was not significant between the two groups before discharge education (p= 0.306 & 0.423) respectively, but after discharge education, a significant difference was observed between the two groups at one month and three months of program implementation (p˂0.000). Besides, postoperative complications were significantly lower for children in the study group at one month and three months of program implementation than in the control group (p˂0.000). Conclusion: Based on the results of the current study, it can be concluded that, the discharge program plays an important role in increasing mother's knowledge, improving children's quality of life and decreasing post-operative complications. Recommendation: All children scheduled for cardiac surgery and their families are in need to an adequate knowledge and self-care skills to improve short and long-term outcomes after discharge.