Mindfulness meditation is a practice that allows one to purposefully pay attention to the present moment without judgment. It helps us to look at things with a new lens and typically change the way to see things. Aim of the study: the aim of the study was to evaluate the effect of the meditation Technique on the psychological and physical body change in children with chronic kidney disease on hemodialysis. Design: A quasi-experimental research design was used to conduct the study. Settings: This study was carried out in pediatric dialysis unit, Benha university Hospital. Sample: A purposive sample of children (47) undergoing hemodialysis therapy through 4 months period in the previously mentioned setting. Tools of data collection: Three tools were used; Tool I:-A structured interviewing questionnaire: Tool II: Pain measurement scale. Tool III: Child and adolescent mindfulness measure. Results of this study revealed that, a highly statistically significant difference of the studied children physiological and psychological change in post application meditation technique. This study concluded that: All children who practice meditation technique experienced significantly less anxiety, depression and experienced decrease in total pain level scores. The study recommended that: Although the effects in this study were not as robust as we had hoped, we still believe mindful meditation to be a promising intervention for children with chronic kidney disease on hemodialysis at different settings