The cyclosporine is now established as the immunosuppressant of choice in human organ transplantation, because it improves graft survival. Unfortunately, the cyclosporine can lead to a wide spectrum of nephrotoxic complications. The aim of this study was to asses the effect of lacidipine (calcium antagonist) on the cyclosporine induced nephrotoxicity in rats. Thirty adult albino rats were used this study. They were divided into three groups: control group, cyclosporine group and lacidipine treated group. The rats of cyclosporine group were received a dose of 50 mg/kg of body weight for two weeks by daily oral administration. The rats of lacidipine treated group were received the same dose of cyclosporine for 14 days along with lacidipine lmg /kg of body weight by daily oral administration three days before and fourteen days concurrently with cyclosporine treatment. At the end of the experiment, there was marked elevation of serum urea and creatinine levels in the cyclosporine group. Lacidipine treatment significantly (P