Staff Members - Benha University
Insulin-Like Growth Factor-IIAs A Tumour Marker In Patients With Hepatocellular Carcinoma
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS • 2017
Publication Information
Authors
Naglaa El-Toukhy1, Badawy A. Abdul Aziz,1Abdelmoneam Ahmed2
and Asmaa Adel3
Keywords
Keywords:Hepatocellular Carcinoma, IGF-II and Alpha fetoprotein.
Journal
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS
Publisher
Not Available
Volume
16
Issue
3
Pages
124-134
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Abstract: Hepatocellular carcinoma (HCC) is one of the most common cancer worldwide that causes death
and in Egypt the burden of HCC is increasing. Prognosis depends on tumor stage. Insulin-like growth factors
(IGFs) play an important role in cancer risk. IGF-II is a polypeptide involved in the proliferation and
differentiation of normal, transformed and malignant hepatocyte. It is anticipated that HCC may produce IGFII,
and serum IGF-II level may increase in patients with HCC so can be used as a serological test for the
diagnosis of HCC. The aim was to assess the value of serum IGF-II in Egyptian patients with HCC. This study
was included 40 patients with HCC, 30 patients with liver cirrhosis and 18 healthy controls. For all groups we
studied clinical data, image findings, serum alpha fetoprotein(AFP) levels detected by enzyme
immunoassay(EIA) kit and IGF-II serum levels were quantified using ELIZA technique. Tumor imaging
characteristics of HCC including size, number and site were assessed. Tumor staging was done using Okuda
,Tokyo staging systems,CLIP and VISUM. The results showed that IGF-II values were higher in HCC cases
than cirrhotics (P1=
and in Egypt the burden of HCC is increasing. Prognosis depends on tumor stage. Insulin-like growth factors
(IGFs) play an important role in cancer risk. IGF-II is a polypeptide involved in the proliferation and
differentiation of normal, transformed and malignant hepatocyte. It is anticipated that HCC may produce IGFII,
and serum IGF-II level may increase in patients with HCC so can be used as a serological test for the
diagnosis of HCC. The aim was to assess the value of serum IGF-II in Egyptian patients with HCC. This study
was included 40 patients with HCC, 30 patients with liver cirrhosis and 18 healthy controls. For all groups we
studied clinical data, image findings, serum alpha fetoprotein(AFP) levels detected by enzyme
immunoassay(EIA) kit and IGF-II serum levels were quantified using ELIZA technique. Tumor imaging
characteristics of HCC including size, number and site were assessed. Tumor staging was done using Okuda
,Tokyo staging systems,CLIP and VISUM. The results showed that IGF-II values were higher in HCC cases
than cirrhotics (P1=