Background: utilization of evidence- based nursing practice guidelines during second stage of labor has become a basic women's' health needs, in order to decrease risks for both women and neonates. Aim of the study: to evaluate the implication of applying evidence- based nursing practice guidelines during second stage of labor on maternal and neonatal outcomes. A Quasi-experimental design was used to conduct the current study at delivery room affiliated to obstetric and gynecologic department, Benha University Hospital during the period from January 2015 to April 2015. Subjects: A simple random sample of 279 Primipara women who selected according to the study formula based on the total number of women who admitted to the above setting during 2014.These were randomly allocated into two groups. study group who, had nursing care according to the utilized evidence based guideline ,control group had ordinary nursing care