Background: Placenta accreta is one of fatal obstetrics crisis that have a negative effect on maternal and neonatal outcomes. Aim: The present study aimed to Study the effect of applying prenatal care protocol for pregnant women with placenta accrete on maternal and neonatal outcomes. Design: A quasi-experimental equivalent study (pre and posttests, non-randomized study) was utilized to fulfill the aim of study. Setting: The study was conducted at Obstetrics and Gynecological outpatient clinic, Obstetrics and Gynecological department and operating room of Obstetrics and Gynecology at Benha university hospital. Sample: A Purposive sample was selected according to inclusion criteria. The sample consisted of 52 women as 3 women diagnosed as placenta previa without accreta at 24 weeks of gestational age . Tools: Data collected through three main tools: I A structured interviewing questionnaire, II Maternal and neonatal outcomes sheet, III Women follow up sheet. Results: There were a highly statistical significant differences between study and control groups regarding attempted placental removal at third stage of labor, hysterectomy, intrapartum blood loss , neonates Apgar score at 1st minute and Apgar score at 5th minute(P< 0.001). Conclusion: Application of prenatal care protocol has positive effect in improving maternal and neonatal outcomes in pregnant women with placenta accreta. Recommendation: Replication of prenatal care protocol on wide range of women diagnosed with placenta accreta.