Objectives: The pandemic of COVID-19 is caused by coronavirus 2 (SARS-CoV-2) and leads to severe acute respiratory syndrome. It has dominated people’s life including their psychosexual health. Consequently, we wanted to examine this pandemic effect on female sexual functions in a sample of Egyptian women. Material and methods: This cross sectional study was conducted at department of dermatology, venerology and andrology of .. Hospitals, included 100 married females 18-45 years’ old during the COVID-19 pandemic. Female Sexual Function Index (FSFI) was utilized to evaluate sexual function, while the psychological aspect was assessed using Beck Depression Inventory (BDI), social readjustment rating, Hamilton anxiety rating, and perceived stress scales. The participants were evaluated by answering retrograde questions about their sexual and psychological state before the the pandemic. Then they re-answered the questionnaires about their present state during the pandemic. Results: Total FSFI scores of the participants showed significant reduction during the pandemic when compared to prepandemic scores (P