The aim of this thesis is tovalidate the effect of iron and erythropoietin treatment on theHbA1c of hemodialysis patients with diabetes. Methods:This study was conducted on 50 HD patients withtype-2 diabetes.All patients were selected from those under going regular HD in nephrology and dialysis unit inBanha University Hospitals. .the diagnosis of diabetes was based on a history of diabetes or on the ADA criteria. The patients classified into two groups (each consists of 25 patients).The first group (group A) are patients selected for iron therapy according to clinical need.The second group (group B) consisted of patients required ESA treatment.Glycemic control in both patient groups were assessed using HbA1c in the month leading up to treatment and once again for a 4-week period 4 months after therapy. Results:A1C value falls after four months of therapy inboth groups(iron and ESA group) compared to before therapy .this change was independent on glycemic control. Conclusions: This study showed that iron and ESA treatments resulted a significant fall in A1C, which was independent on glycemic changes in patients with diabetes and CKD.