Menopause signals the end of women’s reproductive life . It has an important role in future disease risk. For example, an early age at menopause is associated with an increased risk of cardiovascular disease (CVD) and bone fractures. Conversely, an early menopause protects against breast, endometrial and ovarian cancer. loss of ovarian function and subsequent decline in endogenous estrogens play as mediators of these differences in risk. While the relationship between menopausal age and CVD risk is well established, its association with type 2 diabetes, remains unclear. As the few epidemiological studies that have investigated this association yielded conflicting results. However, this association can be explained by several evidences. First, menopause is associated with cessation of ovarian production of estrogen. This decline can be considered as one of the factors that play a pivotal role in development and progression of the metabolic syndrome. This can be observed in postmenopausal women who received estrogen therapy and had a reduction in their fasting plasma glucose (FPG) levels. Second, menopausal transition characterized by changes in the distribution of body fat with increasing in abdominal fat deposition under the effect of low estrogen and high androgen. This is associated with a disturbance in the production of a several hormones as adiponectin , leptin , gherlin that are associated with insulin resistance and the metabolic syndrome. Third, menopause is associated with continuation of androgen & testosterone production, that are associated with glucose intolerance in both premenopausal and postmenopausal women. AS in polycystic ovary syndrome (PCOS) which characterized by higher androgen levels, and greater risk of diabetes.