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publication name EVALUATION OF INACTIVATED RIFT VALLEY FEVER VACCINE WITH PARAFFIN OIL ADJUVANT
Authors GF El-Bagoury; AS El-Habbaa; AM Ibrahim; Noha, E.E. Yousef
year 2013
keywords RVF vaccine, paraffin oil, SNT
journal BENHA VETERINARY MEDICAL JOURNAL
volume 25
issue 1
pages 157-164
publisher Faculty of Vet. Med., Benha University
Local/International International
Paper Link Not Available
Full paper download
Supplementary materials Not Available
Abstract

Rift Valley Fever (RVF) caused by an arbo-virus belonged to genus Phlebovirus, family Bunyaviridae, is an acute, febrile disease of ruminants. In Egypt, immunization of susceptible animals occurs using a locally prepared inactivated vaccine with aluminum hydroxide gel adjuvant. Adjuvants play an important role in vaccine formulation, so, selection of the proper adjuvant can elaborate high and long standing immunity. The aim was to develop a new RVF vaccine with paraffin oil adjuvant in water in oil in water (W/O/W) formula using Tween80 and Arlacel A as surfactants. Evaluation of the immune response to the prepared RVF vaccine in sheep was done in comparison with the local RVF vaccine with using SNT and ELISA. Results gave the priority to the prepared inactivated RVF vaccine with Paraffin oil adjuvant that induced high immunological enhancement without toxicity and with longer duration of immunity that extended for 9 months.

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