Staff Members - Benha University
Trichinella spiralis: infection changes serum paraoxonase-1 levels, lipid profile, and oxidative status in rats
• 2012
Publication Information
Authors
Mido, S., Fath, E. M., Farid, A. S., Nonaka, N., Oku, Y., and Horii, Y.,
Keywords
Not Available
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Paraoxonase-1 (PON1) is an HDL-associated enzyme with anti-atherogenic properties. Reduced PON1
activity has previously been observed in Nippostrongylus brasiliensis-infected rats. However, the effect
of chronic zoonotic nematode infections on serum PON1 activity has not yet been studied. Therefore,
we evaluated the effect of Trichinella spiralis infection on serum PON1 activity, the lipid profile, and oxidative
stress in rats. There were significant reductions in serum PON1 activities (Day 2–Week 7 postinfection)
in rats infected with T. spiralis, and these reductions were associated with significant increases
in the serum levels of triglyceride and LDL/VLDL, as well as a significant reduction in the level of HDL.
Moreover, T. spiralis infection was associated with a status of oxidative stress indicated by increased concentrations of superoxide dismutase and malondialdehyde. Given the zoonotic prevalence of T. spiralisand the cardioprotective role of PON1, further mechanistic research in this area is warranted
activity has previously been observed in Nippostrongylus brasiliensis-infected rats. However, the effect
of chronic zoonotic nematode infections on serum PON1 activity has not yet been studied. Therefore,
we evaluated the effect of Trichinella spiralis infection on serum PON1 activity, the lipid profile, and oxidative
stress in rats. There were significant reductions in serum PON1 activities (Day 2–Week 7 postinfection)
in rats infected with T. spiralis, and these reductions were associated with significant increases
in the serum levels of triglyceride and LDL/VLDL, as well as a significant reduction in the level of HDL.
Moreover, T. spiralis infection was associated with a status of oxidative stress indicated by increased concentrations of superoxide dismutase and malondialdehyde. Given the zoonotic prevalence of T. spiralisand the cardioprotective role of PON1, further mechanistic research in this area is warranted