Background: Lumbar laminectomy is one of the most commonly performed spinal surgical procedures for the treatment of a wide variety of pathologies. The study aim was to evaluate the effect of applying an educational program for patients with lumbar laminectomy on their knowledge and self-care activities. Design: A randomized-controlled trail research design was utilized in this study to achieve the aim of this study. Setting: The study was conducted at neurosurgery department at the Benha University Hospital in the Qualubia Governorate, Egypt. Sample: A purposive sample of 80 adult patients with lumbar laminectomy divided alternatively into two equal groups, 40 patients for each group; study group (I) was received educational program along with the routine hospital care. Control group (II) was received the routine hospital care only .Tools: Four tools were used in the study. Tool (1): Patients' assessment sheet consists of two parts, part 1: Socio-demographic characteristics of patients, part 2: Patients’ health history. Tool (2): knowledge assessment questionnaire Tool (3): Barthel Index of Activities of Daily Living and Tool (4): Visual Analogue Pain scale (VAPS). Results: There no statistical significant differences were existed between both groups in relation to all socio- demographic characteristics except marital status and occupational change at p-value = 0.054 and 0.04 respectively. Conclusion: Providing an educational program to the patients has been shown to be effective for improving knowledge, self-care activities. Recommendation: Replication of the study using a larger probability sample from different geographical areas to attain more generalizable results.