Trichinellosis is a worldwide risky zoonotic nematode infecting people particularly in pig rais- ing countries. The goal of this investigation was to evaluate the effectiveness of Kalobin (Pelargonium reniforme/sidoides) as a therapeutic and a prophylactic treatment of experimental intestinal T. spiralis infection. Consequently, one hundred Swiss albino male mice were divided into five groups of 20 each. GI: untreated, uninfected mice (negative control). GII: infected untreated mice (positive control). GIII: infected treated with Albendazole (ABZ) started three days after infection and continued for three successive days. GIV: infected and treated with Kalobin began 24 hours after infection and went on for 6 consecutive days since infection. GV: infected mice and Kalobin treated started 15 day before infection up to 6 successive days (pretreated group). Two hundred T. spiralis larvae were given orally to all groups except GI and evaluated parasitological, histopathological, and biochemical of the efficacy of treatment.The results showed that both GIII and GV caused substantial decrease in intestinal adults' count than other ones (94.4%, & 52.1% respectively). These results were supported by the enhancement of histology and biochemistry findings.