Nurses working in acute inpatient psychiatry, where lengths of stay are increasingly shortened, are struggling to create therapeutic nurse-patient relationships. Moreover, acute inpatient psychiatric care is an increasingly restricted resource; it is critical that nurses participate with clients in ways that assist them attain the highest health results possible. Aim of this study: This study aimed to evaluate effect of educational program about psychiatric’ nurse-patient relationship on patients’ quality of care. Design: Quasi experimental design was used. Setting: this study carried out at emergency department in Benha psychiatric health hospital. Sample: A Convenient sample of (60) nurses and (60) patients at Benha Psychiatric Health Hospital. Tool: Three tools were used, tool I: Nurse-Patient Relationship Questionnaire, tool II: Nurse–Patient Relationship Observation Checklist Schedule, and tool III: Quality in Psychiatric Care In-patient (QPC-IP) Instrument. Results: there was a positive correlation between nurses’ knowledge about nurse-patient relationship, practice and quality of patients care in pre-program. In addition to a highly positive correlation between nurses’ knowledge about nurse-patient relationship, practice and quality of patients care in post-program. Conclusion: the educational program had a positive effect on nurses’ knowledge about nurse-patient relationship and their practice during this relation that lead to improve quality of patient care. Recommendation: The nurse must acquire the necessary knowledge to participate effectively in therapeutic relationships.