Cisplatin (CP) is used to treat a wide range of tumors and kills cells (anti-neoplastic drug) through different mechanisms, including, formation of reactive oxygen species (ROS), DNA damage, and induction of apoptosis (Almeer and Abdel Moneim., 2018; Jahan et al., 2018; Elkomy et al., 2020; Sallam et al., 2021). While cardiac toxicity is not known to be a common adverse effect of CP, a number of cardiac toxic findings produced during or shortly after CP injection have been reported. These involve moderate and extreme cardiac, vascular adverse reactions, such as cardiac failure, pericarditis, myocarditis, arrhythmia, hypertension, and occasionally, cardiac ischemia, cardiac tamponade, and endomyocardial fibrosis (Topal et al., 2018).