Purpose: The aim of this work is to compare safety and efficacy of mini-perc versus standard PNL in patients with 1-2 cm renal stone in supine position. Material and Methods: A total of 120 percutaneous procedures were performed in 120 patients for renal stones 1-2 cm in size between July 2010 and June 2012 in Urology department of BenhaUniversity. Patients enrolled in the study were randomly allocated into 2 groups, 60 patients underwent conventional PNL and the other group underwent mini-perc. Results: Mini-perc group required significantly longer intra-renal ureteroscopy time; however the reverse is true regarding the fluoroscopy time due to less time needed in tract dilation in mini-perc group. Bleeding was significantly less in mini-perc group reflected by less hematocrit drop in mini-perc group (5.7 ± 1.37 versus 4.8 ± 1.41, P value 0.001). Four patients (6.7 %) in the conventional PNL group needed blood transfusion whereas no patient needed blood transfusion in mini-perc group. Postoperative analgesic requirements were significantly less in mini-perc group than the conventional PNL group ( 115.2 mg ± 18 .7 ) versus (91.8 mg ± 6.5, respectively; p value