Staphylococci form part of the normal flora of humans and a wide variety of animals. Some Staphylococcal species also cause infections for human and household pets, This study was conducted to investigate Coagulase-positive Staphylococci in dogs and cats ,A total of 100 oral swabs were collected from 65 dogs and pet cats,of both sexes from stray and housed pets (27stray and 73 housed), which selected from different clinics and shelters in Cairo and Giza governorates.The prevalence of S. aureus was identified in(3/ 27) 11% cats and in (2/65) 3% dogs . Staphylococcus pseudintermediuswas isolated from one (1%) dogs, The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in dogs was (1/2) and in cats it was (1/3) of isolated strains The prevalence of methicillin-resistant Staphylococcus pseudintermedius (MRSP)was one (1.5%from dog) In conclusion, oral cavity of cats and dogs harbormethicillin-resistant Staphylococcus