Gingival scrapings of 75 dogs and cats (40 dogs- 35 cats) were examined for the presence of Pasteurella multocida. Pasteurella multocida isolated strains were represented by 33 canine isolates and 12 feline isolates, respectively. 50 Sputum samples from bronchial secretions of pet caretakers_were admitted with a 48 hour history of headache, neck stiffness, central pleuritic chest pain relieved by sitting forward and made worse by lying flat, fever, rigors, and drowsiness, with history of contact with stray or Owens cats or dogs. 28 out of 50 cases were positive for Pasteurella multocida in (56%). Assuming that Pasteurella multocida is potentially pathogenic for pet caretakers, 60% of examined cats and dogs harboured pathogenic strain. Serotyping of the isolated strains from dogs, cats and man in the same locality was demonstrated in three serotypes of Pasteurella multocida (A1, A2 and A6) having the possibility of cross infection between dogs, cats and man. Antimicrobial sensitivity test proved that Pasteurella multocida isolated strains were sensitive to Cephalothin (30 mg), Erythromycin (15mg), Streptomycin (10mg), Gentamycin (10mg) Amoxicillin (20mg), and medium resistant to Ampicillin (10mg).