Abstract Aim: To evaluate the analgesic effect of post incisional infiltration and intraperitoneal instillation of long acting local anathetic on post-operative pain in non descent vaginal hysterectomy (NDVH). Design: a randomized, double blind, placebocontrolled study. Setting: Benha University Hospital. Patients and Methods: Forty eight womens undergoing NDVH received 50 ml ropivacine (0.50%) (n = 24) or 50 ml saline (n = 24) by post incisional infiltration (30 ml) and intraperitoneal instillation (20 ml). Main outcome measures: pain "using visual analogue scale (VAS) score", nausea, vomiting and analgesic requirements were recorded for 24 postoperatively as well as time spent in postanesthesia care unit and time to get out of bed. Results: The mean pain VAS score after one, two, four, eight, twelve hours postoperatively were significantly lower in ropivacine group (P