Staff Members - Benha University
Hepatotoxic Evaluation in Albino Rats Exposed to Ceftriaxone
Asian J Pharm Biol Res • 2011
Publication Information
Authors
M.G.A. El-Sayed, A.A. Elkomy and M.H. Aboubakr*
Keywords
Not Available
Journal
Asian J Pharm Biol Res
Publisher
Not Available
Volume
Asian J Pharm Biol Res Apr-Jun 2011 Vol. 1(2)
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Objective: The aim of the present study was to investigate the hepatotoxic effect and biochemical alterations induced by
ceftriaxone in rats.
Methods: Rats were injected ceftriaxone intramuscularly with 180 (therapeutic dose) and 360 (doupletherapeutic dose) mg/kg
b.wt. daily for five consecutive days. Blood and liver samples were collected for quantitative determination of some
biochemical parameters and histopathological examination respectively.
Results: Ceftriaxone produced significant increase in serum concentrations of liver enzymes (AST and ALT), total bilirubin,
cholesterol, Tg and LDL-cholesterol. Ceftriaxone also caused significant decrease in albumin and HDL-cholesterol. Ceftriaxone
injection in the tested doses caused histopathological changes in liver. The severity of these changes was dose dependant.
Conclusion: Hepatic functions should be monitored and/or the dose should be adjusted during ceftriaxone therapy.
Key words: Ceftriaxone, Biochemical, Histopathology, Hepatotoxicity, Rats.
ceftriaxone in rats.
Methods: Rats were injected ceftriaxone intramuscularly with 180 (therapeutic dose) and 360 (doupletherapeutic dose) mg/kg
b.wt. daily for five consecutive days. Blood and liver samples were collected for quantitative determination of some
biochemical parameters and histopathological examination respectively.
Results: Ceftriaxone produced significant increase in serum concentrations of liver enzymes (AST and ALT), total bilirubin,
cholesterol, Tg and LDL-cholesterol. Ceftriaxone also caused significant decrease in albumin and HDL-cholesterol. Ceftriaxone
injection in the tested doses caused histopathological changes in liver. The severity of these changes was dose dependant.
Conclusion: Hepatic functions should be monitored and/or the dose should be adjusted during ceftriaxone therapy.
Key words: Ceftriaxone, Biochemical, Histopathology, Hepatotoxicity, Rats.