The aim of this study was to determine the blood and tissue concentrations profile and effect of tilmicosin on some hematological
and biochemical parameters in broiler chicken. Fifty clinically healthy Hubbard chickens were orally administered 25mg/kg BWof
tilmicosin once daily for 5 consecutive days. Tissue residues of tilmicosin in slaughtered healthy chicken could not be detected by
microbiological assay in all tested tissues except in lung (at 96 hours) and liver and kidneys (at 72 hours) after last administration.
Tilmicosin caused temporary decrease in the RBCs and WBCs counts and has no effect on hemoglobin (Hb) and packed cell
volume concentration (PCV). Also, the effect of tilmicosin on some biochemical parameters was as follows: the concentrations of
creatinine, uric acid, electrolytes (sodium, potassium, and calcium), glucose, AST, ALT, ALP, and HDL-cholesterol in the serum of
treated chicken did not change in response to the repeated oral administration of tilmicosin. Therewere only a temporary significant
decrease in total protein and albumin concentrations and a significant increase in cholesterol and triglycerides concentrations.
Chicken must not be slaughtered before 4 days from the stopping of tilmicosin administration. Tilmicosin makes temporary
changes on hematological and biochemical parameters in broiler chicken.