This study was designed to investigate the prevalence oj anticardioli· pin (aCL), antiphosphatidylserine (aPS) and !32·glycoProtein I (a !32'GPl) antibodies in women with repeated spontaneous abortion (RSA) Qnd reo peated in-vitro jertilization-embryo transjer jailure (NF-ET-F). The study included 45 with three or more RSA oj unknown etiology with the same partner (RSA group), 40 women with. NF·ETjailures o,fter two or more IVF cycles (NF-ET-F group) and 10 normal multiparous healthy non-pregnant women with documented uncomplicated pregnancies (Control group). After jull history taking and complete general and obstetric examination all patient gave blood samples jor determination oj aPS, aCL and a!32-GP1. IgG and IgM antibodies by EUSA. Anticardiolipin antibodies was detected in 12 patients with. RSA (26,7%) and 11 patients (27.5%) with NFjailure, while aPS antibodies were deteCted in 6 (13.3%) and 14 (35%) patients in both groups respectively. There was a signijlcant increase in the number ojpatients with positive aCL and aPS antibodies in both groups, compared to control