Staff Members - Benha University
Anti-Nucleosome Antibodies in Systemic Lupus Erythematosus as a Diagnostic Tool and Useful Marker for Lupus Nephropathy
- Egypt Rheumatology & Rehabilitation • 2008
Publication Information
Authors
Yasser Abdel-Hamid, Ashraf Talaat, Khalid Bilal, Azza Abdul Aziz Abdul Hamid, Youssef El-Bayoumi
Keywords
---
Journal
- Egypt Rheumatology & Rehabilitation
Publisher
- Egypt Rheumatology & Rehabilitation
Volume
V. 34 No. 4
Issue
---
Pages
579 - 595
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Objective: To investigate the clinical utility of anti-nucleosome antibodies (anti-NCS) for the diagnosis of SLE and as a marker of disease activity. Also, to explore their role in biopsy-proven lupus nephritis.
Methodology: The study was conducted on 83 SLE patients diagnosed according to the revised ACR criteria. Serum IgG anti-NCS antibodies were detected with ELISA for the patients and 100 matched apparently healthy subjects as, a control group. Renal biopsies were performed for 44 patients with renal involvement and classified according to the WHO classification criteria.
Results: Serum anti-NCS antibodies levels were significantly higher in patients with renal affection, arthritis (p
Methodology: The study was conducted on 83 SLE patients diagnosed according to the revised ACR criteria. Serum IgG anti-NCS antibodies were detected with ELISA for the patients and 100 matched apparently healthy subjects as, a control group. Renal biopsies were performed for 44 patients with renal involvement and classified according to the WHO classification criteria.
Results: Serum anti-NCS antibodies levels were significantly higher in patients with renal affection, arthritis (p