Background: Congestive heart failure (CHF) is a disease caused by weakening of the heart muscle making it unable to pump a sufficient volume of blood to supply the body’s need for oxygen. The CHF affecting patient's quality of life. Aim of the study: was to assess quality of life for patients with congestive heart failure& factors affecting quality of life for such group of patients at coronary care unit at Benha University Hospital. Methods: A descriptive exploratory research design was used. Study subjects: A sample of 100 patients with CHF admitted to Coronary Care Unit at Benha University Hospital. Two tools were used to collect data (1) Interview questionnaire sheet, (2) The quality of life scale. Results: the present study revealed that the majority of studied subjects (81%) had unsatisfactory level of information regarding CHF and its management and (55%) have poor total QoL. There were many factors that affect the patient's QoL as physical (57%), psychological (68%), social (50%), spiritual (29%) & patient’ beliefs (38%) factors. There was statistically significant (P