Staff Members - Benha University
Bronchoalveolar lavage (BAL) fluid cellularity and ventilatory functions in chronic hepatitis (HCV) patients
Egyptian journal of chest diseases and tuberculosis • 1997
Publication Information
Authors
Hamdy AB, Younis YS, El- nawawiM and Abul-Dahab S
Keywords
Not Available
Journal
Egyptian journal of chest diseases and tuberculosis
Publisher
Not Available
Volume
46
Issue
2
Pages
105-110
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Hepatitis C virus (HG ))infecrion has recenrly been incriminated as an aeriological agent in idiopathic p ulmonary fibrosis (IPF . This study was p erformed to study the cellularity of bronchoalveolar lavage (BAL)fluid and ventilatory function tests in patients with chronic HCV infecrion.
BAL fluid and lavage from ten pa tienrs with chronic active hepariris C, diagnosed by elevated serum
rmnsaminases and rypical histological findings in rhe li1•er. ll'ae analysed (group 1). Lavage findings and ventilatory fimc rions in rhese patienrs were compared with those from ren healthy volunteers as controls (group II). There was no difference in rota/ cell coums in rhe lavage fluid between the Mo g roups, but lavage lymphocyre and.eosinophil numbers were increased in chronic HCV patients. The ventilarory functions FVCo/o and FEV I % predicted and FEV /F VCo/o were significantly lower in the
HCV pa tienrs (group 1). The FVC o/o, EFV 1o/o. FEF 15_75r, c pr edicted and FEV / FVCo/o were lower in rhe HCV p.arients with alveolitis.
Thus, the numbers of lymphocytes and eosinophils in BAL fluid are increased in patients with chronic
HCV. These findings suggest that chronic HCV infection may trigger alveolitis. This alveolitis may de
crease rhe ventilatoryfimctions.
BAL fluid and lavage from ten pa tienrs with chronic active hepariris C, diagnosed by elevated serum
rmnsaminases and rypical histological findings in rhe li1•er. ll'ae analysed (group 1). Lavage findings and ventilatory fimc rions in rhese patienrs were compared with those from ren healthy volunteers as controls (group II). There was no difference in rota/ cell coums in rhe lavage fluid between the Mo g roups, but lavage lymphocyre and.eosinophil numbers were increased in chronic HCV patients. The ventilarory functions FVCo/o and FEV I % predicted and FEV /F VCo/o were significantly lower in the
HCV pa tienrs (group 1). The FVC o/o, EFV 1o/o. FEF 15_75r, c pr edicted and FEV / FVCo/o were lower in rhe HCV p.arients with alveolitis.
Thus, the numbers of lymphocytes and eosinophils in BAL fluid are increased in patients with chronic
HCV. These findings suggest that chronic HCV infection may trigger alveolitis. This alveolitis may de
crease rhe ventilatoryfimctions.