| publication name | Comparison of the percentages of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia |
|---|---|
| Authors | Farha El-Chennawi1 | Ibrahim Mohamed Rageh2 | Amira Ibrahim Mansour2 | Mohammed Ibrahim Darwish1 | Ashraf Antar Elghzaly1 | Basma El Sayed Sakr3 | Khaled Mohsen Elbaz4 |
| year | 2017 |
| keywords | flow cytometry, FOXP3, preeclampsia, regulatory T cells, umbilical cord blood |
| journal | Am J Reprod Immunol |
| volume | Not Available |
| issue | Not Available |
| pages | Not Available |
| publisher | John Wiley & Sons A/S. |
| Local/International | International |
| Paper Link | https://doi.org/10.1111/aji.12761 |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Problem: Little is known about how preeclampsia affects regulatory T- cell count and functions in umbilical cord blood of babies born to preeclamptic mothers. Here, we analyze the percentage of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia. Method of study: The percentage of umbilical cord blood CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs were analyzed by flow cytometry. Results: CD4+ CD25high FOXP3+ Treg (%) and CD4+ FOXP3+ Treg (%) were significantly lower, while CD4+ CD25low (%) was significantly higher in umbilical cord blood of babies born to preeclamptic mothers. Conclusion: Preeclampsia is associated with immune dysregulation which leads to a deficiency in Treg (CD4+ CD25high FOXP3+) in the umbilical cord blood of babies born to preeclamptic mothers.