Staff Members - Benha University
Decrease of serum biomarker of type II Collagen degradation (Coll2-1) by intra-articular injection of an autologous plasma-rich-platelet in patients with unilateral primary knee osteoarthritis
European Journal of Rheumatology • 2017
Publication Information
Authors
Rasha Mohamed Fawzy1
, Nashwa Ismail Hashaad1
, Amira Ibrahim Mansour2
Keywords
Platelet-rich plasma, growth factors, serum coll2-1, knee osteoarthritis, Western Ontario, McMaster Universities Arthritis
Index Score
Journal
European Journal of Rheumatology
Publisher
Medical Research and Education Society
Volume
4
Issue
Not Available
Pages
93-97
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Objective: This study aimed to evaluate the effect of one dose of intra-articular injection of (PRP) in the knee joint on a specific osteoarthritis
(OA) serum biomarker of cartilage degeneration, Collagen 2-1 (Coll2-1), over a short period of 3 months. The aim extended
to clarify the effect of PRP on the functional status of the osteoarthritic knee joint.
Material and Methods: Sixty patients with primary unilateral knee OA were enrolled in this study. They were subdivided according
to Kellgren-Lawrence grading scale (KL) into (Group Ι): including patients with KL grade < 3 and (Group ΙΙ): including patients with KL
grade ≥3. Patients were asked to complete the Western Ontario and McMaster Universities Arthritis Index (WOMAC) Score. PRP was
prepared and injected immediately into the affected knee. Serum Coll2-1 (S.Coll2-1) concentration was measured by enzyme-linked
immunosorbent assay (ELISA) kit pre and 3 months after PRP injection.
Results: Significant reduction in S.Coll2-1 concentration in primary knee OA patients; (p
(OA) serum biomarker of cartilage degeneration, Collagen 2-1 (Coll2-1), over a short period of 3 months. The aim extended
to clarify the effect of PRP on the functional status of the osteoarthritic knee joint.
Material and Methods: Sixty patients with primary unilateral knee OA were enrolled in this study. They were subdivided according
to Kellgren-Lawrence grading scale (KL) into (Group Ι): including patients with KL grade < 3 and (Group ΙΙ): including patients with KL
grade ≥3. Patients were asked to complete the Western Ontario and McMaster Universities Arthritis Index (WOMAC) Score. PRP was
prepared and injected immediately into the affected knee. Serum Coll2-1 (S.Coll2-1) concentration was measured by enzyme-linked
immunosorbent assay (ELISA) kit pre and 3 months after PRP injection.
Results: Significant reduction in S.Coll2-1 concentration in primary knee OA patients; (p