Background: Helicobacter pylori (H. pylori) has been shown to
be a key contributor to chronic gastritis. Peptic ulcer disease,
gastric adenocarcinoma, and gastric lymphoma are all linked to
this condition, which affects 50% of the world's population.
Aim of the work : To assess the efficacy of adding vitamin D
supplement in eliminating helicobacter pylori infection.
Methods: A total of 50 Egyptian patients with dyspeptic
symptoms lasting at least one month were involved in this case
study. Patients were categorized into two groups. Group A: 25
patients with helicobacter pylori infection ; they received
clarithromycin-based triple treatment and a vitamin D
supplement Group B : 25 individuals with Helicobacter pylori
infection ; they received triple clarithromycin treatment without
vitamin D supplementation. Results: There was a statistically
significant difference (p= 0.031) in the efficacy of vitamin D
between the two groups, with 84% of patients in group A
showing favourable outcomes whereas only 56% of the patients in group B exhibited positive
results. Conclusion: As a result, supplementing clarithromycin-based triple therapy with vitamin
D3 may increase eradication rates for H. pylori infections substantially.