Context: Cataract is the leading cause of poor vision worldwide. Patients who knowledgeable and skillful nurses well prepare are better prepared to engage in appropriate self-care activities post-cataract surgery. Aim: This study aimed to assess the effectiveness of nursing intervention protocol on nurses' performance and patients’ self-care after cataract surgery. Methods: The study followed a quasi-experimental, pretest-posttest design. The study was conducted in ophthalmology surgical inpatient units and the outpatient clinics at Benha University Hospital. The sample consisted of all available nurses (35) working in the ophthalmology surgical inpatient units, and the outpatient clinics who are willing and agreed to participate in the study and a convenient sample consisted of 50 patients of both genders were also included in the current study before implementing nursing intervention protocol. Three tools were used to conduct the study: A structured interview questionnaire, nurses' practice checklist, and patients’ self-care activity checklist. Results: The results showed statistically significant improvements in nurses' performance (knowledge and practice) immediately post and one-month follow-up post-nursing intervention protocol compared with pre-nursing intervention protocol implementation (p