Objective: Was to investigate the effect of black seed oil versus sesame oil to enhance external and internal anal hemorrhoids healing. Design: Follow-up intervention study was utilized. Sample: A convenience sample was obtained. The study duration was through one year started from Mars 2012 to Mars 2013. Sample size: 120 mothers medically diagnosed with anal external or internal anal hemorrhoids were divided equally into two groups: Group (A) received black seed oil and group (B) received sesame seed oil. Tools: Two tools were utilized a pre-structured interviewing questionnaire and observational checklist that involves Visual Analogue Scale to assess hemorrhoids pain and Reeda Scale to assess hemorrhoids healing. Results: In both black seed oil and sesame oil groups, there were a highly significant improvement in both pain symptoms and enhancement of hemorrhoids healing postintervention compared to pre-intervention (p