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Role of Anti-nucleosome Antibodies in the Diagnosis of Systemic Lupus Erythematosus and as A Marker for Lupus Nephropathy
THE EGYPTIAN JOURNAL OF IMMUNOLOGY • 2014
Publication Information
Authors
Eman R Abdel Gawad, 1Amira I Mansour, 2Yasser A Abdel Aziz, 2Aml F. Soliman, 2Rasha M. Fawzy
Keywords
Anti-nucleosome Antibodies Lupus Nephropath
Journal
THE EGYPTIAN JOURNAL OF IMMUNOLOGY
Publisher
Not Available
Volume
21
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
SLE is a heterogeneous disease, characterized by variation in clinical and serological manifestations. This study intended to verify the role of anti-nucleosome (anti-NCS) antibodies in diagnosis of SLE and lupus nephritis and to establish the correlation between antibody reactivity and disease activity. Study subjects included 35 patients diagnosed as SLE and two control groups. While the first is a group with other collagen diseases (n=80), the second included 50 matched apparently healthy subjects. Serum IgG anti-NCS antibodies in all subjects were detected by ELISA. Serum anti-NCS were higher in SLE than in the two control groups (
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