High-fidelity simulation is a learning method consisting on reproduction of medical scenarios through the use of a computerized manikin that can be programmed to recreate clinical conditions and to react to learners’ actions in a controlled and safe setting. Aim of the study: The aim of the study is to assess effect of high-fidelity simulation training on pediatric nursing student's knowledge, practice and attitude regarding cardiopulmonary resuscitation. Design: A quasi-experimental research design was used to conduct the study. Settings: This study was carried out in clinical pediatric laboratory skills for third year student’s and teaching hall of Faculty of Nursing / Benha University. Sample: A systematic random sample of 111 pediatric nursing students from pediatric nursing department, third year. Tools of data collection: three tools were used: tool (1) A structured interviewing questionnaire that was constructed by the researcher including two parts and tool (2) observational check list sheet and tool (3) attitude of pediatric nursing student’s regarding cardiopulmonary resuscitation. Results: The results showed that, there was a highly statistical significant difference in the studied student’s total knowledge, attitude and practice scores in favor of post training. Conclusion: The study concluded that, our study finding add more support in favor of high-fidelity simulation evidence by an obvious improvement of studied students' knowledge, practice and attitude scores after training.Recommendations: The study recommended that nursing education programs should adopt high fidelity simulation in undergraduate education.