Mindfulness meditation is a practice that allows one to purposefully pay attention to the present moment without judgment. It helps us to look at things with a new lens and typically change the way to see things. Aim of the study: the aim of the study was to evaluate the effect of the meditation Technique on the psychological and physical body change in children with chronic kidney disease on hemodialysis. Design: A quasi-experimental research design was used to conduct the study. Settings: This study was carried out in pediatric dialysis unit, Benha university Hospital. Sample: A purposive sample of children (47) undergoing hemodialysis therapy through 4 months period in the previously mentioned setting.. Tools of data collection: Three tools were used; Tool I:-A structured interviewing questionnaire: Tool II: Pain measurement scale. Tool III: Child and adolescent mindfulness measure. Results of this study revealed that, a highly statistically significant difference of the studied children physiological and psychological change pre and post application meditation technique. This study concluded that: Application of the meditation technique improved the physiological and psychological change and less sever pain on children with chronic kidney disease on hemodialysis. All children who practice meditation technique experienced significantly less anxiety, depression and experienced decrease in total pain level scores. In addition, a decrease in sympathetic activity occurred after practicing meditation technique, children having meditation express lower pulse and respiration rate and blood pressure post meditation than pre meditation. The study recommended that : Although the effects in this study were not as robust as we had hoped, we still believe mindful meditation to be a promising intervention for children with chronic kidney disease on hemodialysis at different settings.