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The protective effect of garlic on changes in liver and brain proteins occurring in albino rats exposed to 900 mhz (gsm) microwaves
MEDICAL • 2005
Publication Information
Authors
Sharaf-Eldeen, Kh. M.; Zowail, M. E. M. and Abdel-Kareim, A. M
Keywords
Mobile phone, electrophoresis, protein, liver, brain, garlic
Journal
MEDICAL
Publisher
ZAGAZIG UNIVERSITY
Volume
VOL. XI,
Issue
3
Pages
Not Available
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Garlic (Allium sativum ) has been used as a medicinal agent for thousands of years. In the present work the radioprotection of this agent will be
investigated. Fourty five mature female albino rats,
Rattus norvegicus
were
allotted into groups and exposed to mobile phone microwave (MP) of 900
MHz for 14, 30 or 45 days. The effect of garlic treatment in association with
the MP exposure was also studied. Protein expression was examined in both
liver and brain tissues by using SDS-polyacrylamide gel electrophoresis. The
results showed that MP exposure caused induction of newly synthesized
polypeptides in liver and brain tissues. On the other hand, the daily
administration of 20mg/kg garlic decreased the number of protein fractions in
liver while such fractions were increased in brain tissue and this effect was
associated especially in liver tissue with expression of new proteins which
maybe stress proteins; these proteins have low molecular weight. Also, garlic
prevented significantly the depression of mitotic index (MI) that occurred
under the effect of MP exposure. The present work suggested the
in vivo
radioprotective role, antimutagenic and anticarcinogenic effect of garlic.
investigated. Fourty five mature female albino rats,
Rattus norvegicus
were
allotted into groups and exposed to mobile phone microwave (MP) of 900
MHz for 14, 30 or 45 days. The effect of garlic treatment in association with
the MP exposure was also studied. Protein expression was examined in both
liver and brain tissues by using SDS-polyacrylamide gel electrophoresis. The
results showed that MP exposure caused induction of newly synthesized
polypeptides in liver and brain tissues. On the other hand, the daily
administration of 20mg/kg garlic decreased the number of protein fractions in
liver while such fractions were increased in brain tissue and this effect was
associated especially in liver tissue with expression of new proteins which
maybe stress proteins; these proteins have low molecular weight. Also, garlic
prevented significantly the depression of mitotic index (MI) that occurred
under the effect of MP exposure. The present work suggested the
in vivo
radioprotective role, antimutagenic and anticarcinogenic effect of garlic.