Staff Members - Benha University
Angiotensin‐converting enzyme gene insertion/deletion polymorphism and family history in severe acne vulgaris
• 2019
Publication Information
Authors
Neveen E. Sorour MD1 | Amany I. Mustafa MD1 | Naglaa F. Alhusseni MD2 |
Eman Fawzy PhD3 | Aml G. Amer MBBCH1
Keywords
acne vulgaris, angiotensin‐converting enzyme, gene polymorphism
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background: Acne vulgaris is an inflammatory disorder with a profound heterogenous
aetio‐pathophysiology. ACE gene I/D polymorphism affects angiotensin‐converting
enzyme activities that play a role in inflammation. However, there are no
molecular genetic studies investigating the contribution of ACE gene insertion/deletion
polymorphism in the genetic background of acne vulgaris.
Aims: The aim of this work was to reveal the relation between the ACE gene I/D polymorphism
and acne vulgaris development among a sample of patients.
Patients and Methods: This study included 100 acne vulgaris patients in addition to
120 matched control subjects. The ACE gene I/D polymorphism was analyzed using
polymerase chain reaction (PCR).
Results: The distribution of DD, ID genotypes, and D allele showed higher frequency
in AV patients than in controls (P < 0.001 for all). Moreover, positive family history
and ACEI/D gene polymorphism (DD + ID genotypes) were considered as independent
predictors for severe acne grades (P ≤ 0.001 and 0.046, respectively) in multivariate
analysis.
Conclusions: The current study results suggest that the D allele of the ACE I/D gene
polymorphism might confer risk to AV among the studied patients. Moreover, ACE
I/D gene polymorphism and positive family history were considered as independent
predictors of severe AV.
aetio‐pathophysiology. ACE gene I/D polymorphism affects angiotensin‐converting
enzyme activities that play a role in inflammation. However, there are no
molecular genetic studies investigating the contribution of ACE gene insertion/deletion
polymorphism in the genetic background of acne vulgaris.
Aims: The aim of this work was to reveal the relation between the ACE gene I/D polymorphism
and acne vulgaris development among a sample of patients.
Patients and Methods: This study included 100 acne vulgaris patients in addition to
120 matched control subjects. The ACE gene I/D polymorphism was analyzed using
polymerase chain reaction (PCR).
Results: The distribution of DD, ID genotypes, and D allele showed higher frequency
in AV patients than in controls (P < 0.001 for all). Moreover, positive family history
and ACEI/D gene polymorphism (DD + ID genotypes) were considered as independent
predictors for severe acne grades (P ≤ 0.001 and 0.046, respectively) in multivariate
analysis.
Conclusions: The current study results suggest that the D allele of the ACE I/D gene
polymorphism might confer risk to AV among the studied patients. Moreover, ACE
I/D gene polymorphism and positive family history were considered as independent
predictors of severe AV.