Abstract
The aim of this study was to investigate the effects of ivabradine against doxorubicin (DOX) –induced cardiotoxicity in rats.
Material and methods A total of 28 female rats were randomly classified into 4 groups: (a) control (n=6 rats), (b) doxorubicin (DOX-treated group) (n=7 rats) received single dose of DOX (20mg/kg, i.p), (c) DOX+ ivabradin treated group (n= 8 rats) (10 mg/kg p.o.) ivabradine 1 h before the DOX treatment and continued for 10 days and ivabradine group (n=7 rats) received ivabradine (10mg/kg/day p.o) for 10 days. Electrocardiogram, heart rate, blood pressure, biochemical markers of oxidative stress, serum creatine kinase level and histopathological changes were measured before and10 days after the beginning of drugs.
Results of the present work showed that ivabradine decreased heart rate; attenuated doxorubicin -induced elevation of oxidative stress and histopathological change.
Conclusion: ivabradine showed protective effect against doxorubicin induced cardiomyopathy. This may be partly through heart rate lowering effect of ivabradine, and decreased oxidative stress.